SenseLab
Computational model
  Data
Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability.
  • Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Show Other
Golgi_cell_NaKATPAse
  • Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br] Show Other
152
True
False
Other categories referring to Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
Revisions: 25
Last Time: 6/7/2018 4:02:17 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin