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Data
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Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
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Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability.
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Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Show
Other
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Golgi_cell_NaKATPAse
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Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br] Show
Other
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152
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