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Data
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Prediction for the presence of voltage-gated Ca2+ channels in myelinated central axons (Brown 2003)
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"The objective of this current study was to investigate whether voltage gated Ca(2+) channels are present
on axons of the adult rat optic nerve (RON).
Simulations of axonal excitability using a Hodgkin-Huxley based
one-compartment model incorporating I(Na), I(K) and leak currents were used to predict conditions under
which the potential contribution of a Ca(2+) current to an evoked action potential could be measured.
... , as predicted by the simulation, reducing the repolarizing effect of I(K) by adding the
K(+) channel blocker 4-AP revealed a Ca(2+) component on the repolarizing phase of the action potential that
was blocked by the Ca(2+) channel inhibitor nifedipine."
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Wu, Sheng-Nan [snwu at mail.ncku.edu.tw] Show
Other
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wshengnan@vcu.edu
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myelinated central axon
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Brown AM. A modeling study predicts the presence of voltage gated Ca(2+) channels on myelinated central axons. Comput Meth Prog Biomed 2003;71:25-31.
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