|
|
|
Data
|
Striatal GABAergic microcircuit, dopamine-modulated cell assemblies (Humphries et al. 2009)
|
|
|
|
|
|
|
To begin identifying potential dynamically-defined computational elements within the striatum, we constructed a new three-dimensional model of the striatal microcircuit's connectivity, and instantiated this with our dopamine-modulated neuron models of the MSNs and FSIs. A new model of gap junctions between the FSIs was introduced and tuned to experimental data. We introduced a novel multiple spike-train analysis method, and apply this to the outputs of the model to find groups of synchronised neurons at multiple time-scales. We found that, with realistic in vivo background input, small assemblies of synchronised MSNs spontaneously appeared, consistent with experimental observations, and that the number of assemblies and the time-scale of synchronisation was strongly dependent on the simulated concentration of dopamine. We also showed that feed-forward inhibition from the FSIs counter-intuitively increases the firing rate of the MSNs.
|
|
|
-
Neostriatum fast spiking interneuron Show
Other
|
|
|
|
|
|
|
|
|
|
|
-
Humphries MD, Wood R, Gurney K (2009) Show
Other
|
|
|
|
|
|
|
|
|
|
-
Humphries, Mark D [m.d.humphries at shef.ac.uk] Show
Other
-
Wood, Ric [ric.wood at shef.ac.uk] Show
Other
|
m.d.humphries@sheffield.ac.uk
|
Striatal medium spiny neuron
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Wood, Ric <ric.wood@shef.ac.uk>
|
|
|
Humphries, M. D.; Wood, R. & Gurney, K. (2009) Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit Neural Networks, 22, 1174-1188
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
