BrainPharm: Computational model - Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)

Computational model

Data

Name

Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)

Submitter name

Pipeline ID

Model File

ShuEtAl20062007_r1 [?]

Notes

" ... Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca21- dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals."

Model Neurons

Neocortex L5/6 pyramidal GLU cell Show Other

More Cells

Model Currents

I Na,t Show Other
I L high threshold Show Other
I A Show Other
I K Show Other
I M Show Other
I h Show Other
I K,Ca Show Other
I_AHP Show Other
I_KD Show Other

Model Receptors

GabaA Show Other
AMPA Show Other
NMDA Show Other

Model Type

Neuron or other electrically excitable cell Show Other
Axon Show Other

Model Concept

Action Potential Initiation Show Other
Detailed Neuronal Models Show Other
Action Potentials Show Other
Synaptic Integration Show Other

Simulator software

NEURON Show Other

Model papers

Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Show Other
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

ShuEtAl20062007

Region Organism

Model ID Number

Gap Junctions

Implemented by

Public Submitter Email Address

tom.morse@yale.edu

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

True

Component

RAM

Hide Auto-launch button

False

Run Protocols

135787_2 Show Other
135787_1 Show Other

ICG Channel Details

Species

Other categories referring to Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)

Revisions:	8
Last Time:	1/2/2015 10:38:16 PM
Reviewer:	Robert A McDougal
Owner:	Tom Morse - MoldelDB admin