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Data
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High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
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"... Using a physiological computer model of hippocampus, we investigate random synaptic activity
(noise) as a potential initiator of HFOs (high-frequency oscillations).
We explore parameters necessary to produce these oscillations and quantify the response
using the tools of stochastic resonance (SR) and coherence resonance
(CR).
...
Our results show that, under normal coupling conditions, synaptic noise was able to produce
gamma (30–100 Hz) frequency oscillations.
Synaptic noise generated HFOs in the ripple range (100–200 Hz) when the network had
parameters similar to pathological findings in epilepsy: increased gap
junctions or recurrent synaptic connections, loss of inhibitory interneurons
such as basket cells, and increased synaptic noise.
...
We propose that increased synaptic noise and physiological coupling mechanisms are sufficient to generate gamma
oscillations and that pathologic changes in noise and coupling similar
to those in epilepsy can produce abnormal ripples."
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Hippocampus CA1 pyramidal GLU cell Show
Other
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Hippocampus CA3 pyramidal GLU cell Show
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Hippocampus CA1 interneuron oriens alveus GABA cell Show
Other
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Stacey WC, Lazarewicz MT, Litt B (2009) Show
Other
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Lazarewicz, Maciej [mlazarew at gmu.edu] Show
Other
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Stacey, William [wstacey at med.umich.edu] Show
Other
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tom.morse@yale.edu
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