BrainPharm: Computational model - Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)

Computational model

Data

Name

Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)

Submitter name

Pipeline ID

Model File

Edgerton_etal_2010_GPmodel [?]

Notes

A set of 9 multi-compartmental rat GP neuron models (585 compartments) differing only in their expression of dendritic fast sodium channels were compared in their synaptic integration properties. Dendritic fast sodium channels were found to increase the importance of distal synapses (both excitatory AND inhibitory), increase spike timing variability with in vivo-like synaptic input, and make the model neurons highly sensitive to clustered synchronous excitation.

Model Neurons

More Cells

Globus pallidus neuron Show Other

Model Currents

I Na,p Show Other
I Na,t Show Other
I A Show Other
I K Show Other
I h Show Other
I K,Ca Show Other
I Calcium Show Other

Model Receptors

GabaA Show Other
AMPA Show Other

Model Type

Neuron or other electrically excitable cell Show Other
Axon Show Other
Synapse Show Other
Channel/Receptor Show Other
Dendrite Show Other

Model Concept

Action Potential Initiation Show Other
Dendritic Action Potentials Show Other
Coincidence Detection Show Other
Active Dendrites Show Other
Influence of Dendritic Geometry Show Other
Detailed Neuronal Models Show Other
Synaptic Integration Show Other

Simulator software

GENESIS Show Other

Model papers

Edgerton JR, Hanson JE, Günay C, Jaeger D (2010) Show Other
Edgerton JR, Jaeger D (2011) Show Other

Gene

Kv4.1 KCND1 Show Other

hg folder name (applicable when in ModelDB hg)

Region Organism

Basal ganglia Show Other

Model ID Number

Gap Junctions

Implemented by

Gunay, Cengiz [cgunay at emory.edu] Show Other
Edgerton, Jeremy R. [jedgert at emory.edu] Show Other
Hanson, Jesse E. Show Other
Jaeger, Dieter [djaeger at emory.edu] Show Other

Public Submitter Email Address

jedgert@emory.edu

Other Neuron

Model Neurotransmitters

Gaba Show Other
Glutamate Show Other

Other Receptor

Other Current

Ih or I_HCN

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

J Neurosci 30: 15146-59. http://www.ncbi.nlm.nih.gov/pubmed/21068320

Default File Notes

Other Gene

Kv4.1 KCND1

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)

Revisions:	9
Last Time:	9/21/2011 2:55:53 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin