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Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010)
"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential-associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."
  • Neocortex V1 L6 pyramidal corticothalamic GLU cell Show Other
  • Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Show Other
  • Fleidervish, Ilya [ilya.fleidervish at gmail.com] Show Other
tom.morse@yale.edu
20543843
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Last Time: 4/14/2017 6:01:26 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin