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Effect of trp-like current on APs during exposure to sinusoidal voltage (Chen et al. 2010)
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Previous work showed that magnetic electrical field-induced antinoceptive action is mediated by activation of capsaicin-sensitive sensory afferents. In this study, a modified Hodgkin-Huxley model, in which TRP-like current (I-TRP) was incorporated, was implemented to predict the firing behavior of action potentials (APs), as the model neuron was exposed to sinusoidal changes in externally-applied voltage.
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Our simulation results suggest that modulation of TRP-like channels functionally expressed in small-diameter peripheral sensory neurons should be an important mechanism through which it can contribute to the firing pattern of APs."
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Chen BS, Lo YC, Lius YC, Wu SN (2010) Show
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Wu, Sheng-Nan [snwu at mail.ncku.edu.tw] Show
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snwu@mail.ncku.edu.tw
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Chen BS, Lo YC, Liu YC, Wu SN. Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage. Chinese Journal of Physiology 2010; 53(6):423-429.
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