BrainPharm: Computational model - CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)

Computational model

Data

Name

CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)

Submitter name

Pipeline ID

Model File

Schizophr [49737]

Notes

NEURON files from the paper: A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. by M. Migliore, I. De Blasi, D. Tegolo, R. Migliore, Neural Networks,(2011), doi:10.1016/j.neunet.2011.01.001. Starting from the experimentally supported assumption on hippocampal neurons we explore an experimentally testable prediction at the single neuron level. The model shows how and to what extent a pathological hypofunction of a contextdependent distal input on a CA1 neuron can generate hallucinations by altering the normal recall of objects on which the neuron has been previously tuned. The results suggest that a change in the context during the recall phase may cause an occasional but very significant change in the set of active dendrites used for features recognition, leading to a distorted perception of objects.

Model Neurons

Hippocampus CA1 pyramidal GLU cell Show Other

More Cells

Model Currents

I Na,t Show Other
I A Show Other
I K Show Other
I h Show Other
I Potassium Show Other

Model Receptors

AMPA Show Other

Model Type

Dendrite Show Other

Model Concept

Dendritic Action Potentials Show Other
Coincidence Detection Show Other
Active Dendrites Show Other
Influence of Dendritic Geometry Show Other
Detailed Neuronal Models Show Other
Action Potentials Show Other
Synaptic Integration Show Other
Schizophrenia Show Other
Hallucinations Show Other

Simulator software

NEURON Show Other

Model papers

Migliore M, De Blasi I, Tegolo D, Migliore R (2011) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

138205

Region Organism

Hippocampus Show Other

Model ID Number

Gap Junctions

Implemented by

Migliore, Michele [Michele.Migliore at Yale.edu] Show Other

Public Submitter Email Address

michele.migliore@pa.ibf.cnr.it

Other Neuron

Model Neurotransmitters

Glutamate Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Migliore M, De Blasi I, Tegolo D, Migliore R (2011) A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. Neural Networks, doi:10.1016/j.neunet.2011.01.001

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

True

Component

RAM

Hide Auto-launch button

False

Run Protocols

138205 Show Other

ICG Channel Details

Species

Other categories referring to CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)

Revisions:	16
Last Time:	11/4/2022 12:37:33 PM
Reviewer:	System Administrator
Owner:	Tom Morse - MoldelDB admin