SenseLab
Computational model
  Data
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
Schizophr [?]
NEURON files from the paper: A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. by M. Migliore, I. De Blasi, D. Tegolo, R. Migliore, Neural Networks,(2011), doi:10.1016/j.neunet.2011.01.001. Starting from the experimentally supported assumption on hippocampal neurons we explore an experimentally testable prediction at the single neuron level. The model shows how and to what extent a pathological hypofunction of a contextdependent distal input on a CA1 neuron can generate hallucinations by altering the normal recall of objects on which the neuron has been previously tuned. The results suggest that a change in the context during the recall phase may cause an occasional but very significant change in the set of active dendrites used for features recognition, leading to a distorted perception of objects.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Migliore M, De Blasi I, Tegolo D, Migliore R (2011) Show Other
  • Migliore, Michele [Michele.Migliore at Yale.edu] Show Other
michele.migliore@pa.ibf.cnr.it
Migliore M, De Blasi I, Tegolo D, Migliore R (2011) A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. Neural Networks, doi:10.1016/j.neunet.2011.01.001
True
False
Other categories referring to CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
Revisions: 14
Last Time: 8/11/2017 7:47:21 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin