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Data
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Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
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"Abnormalities in oscillations have been suggested to play a role in schizophrenia.
We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and
without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic.
Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare,
OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells
primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta.
..."
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Hippocampus CA3 pyramidal GLU cell Show
Other
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Hippocampus CA3 interneuron basket GABA cell Show
Other
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Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron Show
Other
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Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Show
Other
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hpcdemo
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Lazarewicz, Maciej [mlazarew at gmu.edu] Show
Other
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Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show
Other
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basket cell, oriens-lacunosum moleculare interneur
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Mohamed Sherif
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