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Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
hpcdemo_r4 [254739]
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
  • Hippocampus CA3 pyramidal GLU cell Show Other
  • Hippocampus CA3 interneuron basket GABA cell Show Other
  • Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron Show Other
  • Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Show Other
hpcdemo
  • Lazarewicz, Maciej [mlazarew at gmu.edu] Show Other
  • Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show Other
basket cell, oriens-lacunosum moleculare interneur
Mohamed Sherif
False
False
Other categories referring to Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Revisions: 24
Last Time: 3/18/2017 10:14:43 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Samuel Neymotin