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Data
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Dorsal root ganglion (DRG) neuronal model (Kovalsky et al. 2009)
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This model, diverged from oscillatory parameters seen in live cells and failed to produce characteristic ectopic discharge patterns. Here we show that use of a more complete set of Na+ conductances--which includes several delayed components--enables simulation of the entire repertoire of oscillation-triggered electrogenic phenomena seen in live dorsal root ganglion (DRG) neurons. This includes a physiological window of induction and natural patterns of spike discharge. An INa+ component at 2-20 ms was particularly important, even though it represented only a tiny fraction of overall INa+ amplitude. With the addition of a delayed rectifier IK+ the singlet firing seen in some DRG neurons can also be simulated. The model reveals the key conductances that underlie afferent ectopia, conductances that are potentially attractive targets in the search for more effective treatments of neuropathic pain.
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Neuron or other electrically excitable cell Show
Other
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Kovalsky Y, Amir R, Devor M (2009) Show
Other
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Devor, Marshall [marshlu at vms.huji.ac.il] Show
Other
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lee.dongchul@gmail.com
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Devor, Marshall <marshlu@vms.huji.ac.il >
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http://www.ncbi.nlm.nih.gov/pubmed/19571204
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