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Detailed passive cable model of Dentate Gyrus Basket Cells (Norenberg et al. 2010)
DG_BC [?]
Fast-spiking, parvalbumin-expressing basket cells (BCs) play a key role in feedforward and feedback inhibition in the hippocampus. ... To quantitatively address this question, we developed detailed passive cable models of BCs in the dentate gyrus based on dual somatic or somatodendritic recordings and complete morphologic reconstructions. Both specific membrane capacitance and axial resistivity were comparable to those of pyramidal neurons, but the average somatodendritic specific membrane resistance (R(m)) was substantially lower in BCs. Furthermore, R(m) was markedly nonuniform, being lowest in soma and proximal dendrites, intermediate in distal dendrites, and highest in the axon. ... Further computational analysis revealed that these unique cable properties accelerate the time course of synaptic potentials at the soma in response to fast inputs, while boosting the efficacy of slow distal inputs. These properties will facilitate both rapid phasic and efficient tonic activation of BCs in hippocampal microcircuits.
  • Nörenberg A, Hu H, Vida I, Bartos M, Jonas P (2010) Show Other
  • Matthia (Norenberg), Anja [anja.matthiae at charite.de] Show Other
Matthiä (Nörenberg), Anja
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Revisions: 14
Last Time: 2/6/2014 5:15:53 PM
Reviewer: Robert A McDougal
Owner: Anja Matthiae