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Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)
"Selective optogenetic drive of fast-spiking (FS) interneurons (INs) leads to enhanced local field potential (LFP) power across the traditional “gamma” frequency band (20–80 Hz; Cardin et al., 2009). In contrast, drive to regular-spiking (RS) pyramidal cells enhances power at lower frequencies, with a peak at 8 Hz. The first result is consistent with previous computational studies emphasizing the role of FS and the time constant of GABAA synaptic inhibition in gamma rhythmicity. However, the same theoretical models do not typically predict low-frequency LFP enhancement with RS drive. To develop hypotheses as to how the same network can support these contrasting behaviors, we constructed a biophysically principled network model of primary somatosensory neocortex containing FS, RS, and low-threshold spiking (LTS) INs. ..."
  • Neocortex L2/3 pyramidal GLU cell Show Other
  • Neocortex fast spiking (FS) interneuron Show Other
  • Neocortex spiking regular (RS) neuron Show Other
  • Neocortex spiking low threshold (LTS) neuron Show Other
  • Vierling-Claassen D, Cardin JA, Moore CI, Jones SR (2010) Show Other
tom.morse@yale.edu
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Revisions: 5
Last Time: 10/18/2018 5:24:41 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin