|
|
|
Data
|
Thalamic network model of deep brain stimulation in essential tremor (Birdno et al. 2012)
|
|
|
|
|
|
|
"... Thus the decreased effectiveness
of temporally irregular DBS trains is due to long pauses in the
stimulus trains, not the degree of temporal irregularity alone.
We also
conducted computer simulations of neuronal responses to the experimental
stimulus trains using a biophysical model of the thalamic
network.
Trains that suppressed tremor in volunteers also suppressed
fluctuations in thalamic transmembrane potential at the frequency
associated with cerebellar burst-driver inputs.
Clinical and computational
findings indicate that DBS suppresses tremor by masking burst-driver
inputs to the thalamus and that pauses in stimulation prevent
such masking. Although stimulation of other anatomic targets may
provide tremor suppression, we propose that the most relevant neuronal
targets for effective tremor suppression are the afferent cerebellar
fibers that terminate in the thalamus."
|
-
Thalamus geniculate nucleus/lateral principal GLU cell Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
|
-
Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM (2012) Show
Other
-
Yi G, Grill WM (2018) Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
merrill.birdno@gmail.com
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
