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Data
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Epileptic seizure model with Morris-Lecar neurons (Beverlin and Netoff 2011)
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Here we use phase-response curves (PRC) from Morris-Lecar (M-L) model neurons with synaptic depression and gradually decrease input current to cells within a network simulation. This method effectively decreases firing rates resulting in a shift to greater network synchrony illustrating a possible mechanism of the transition phenomenon. PRCs are measured from the M-L conductance based model cell with a range of input currents within the limit cycle. A large network of 3000 excitatory neurons is simulated with a network topology generated from second-order statistics which allows a range of population synchrony. The population synchrony of the oscillating cells is measured with the Kuramoto order parameter, which reveals a transition from tonic to clonic phase exhibited by our model network.
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Beverlin B, Kakalios J, Nykamp D, Netoff TI (2012) Show
Other
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beverlin@physics.umn.edu
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Morris-Lecar
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Beverlin, Bryce
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