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Data
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CA1 pyramidal neuron dendritic spine with plasticity (O`Donnell et al. 2011)
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Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule.
The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.
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Hippocampus CA1 pyramidal GLU cell Show
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O'Donnell C, Nolan MF, van Rossum MC (2011) Show
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O`Donnell, Cian [cian AT salk.edu] Show
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cian@salk.edu
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O Donnell, Cian <cian@salk.edu>
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