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Data
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CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
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This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer
collateral synapse stimulation. In the model, the peak calcium concentration is highly
correlated with soma-synapse distance under a number of physiologically-realistic
suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy
in a homeostatic manner, whereby synapses regulate their synaptic strength on the
basis of the difference between peak calcium and a uniform target value.
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Hippocampus CA1 pyramidal GLU cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Show
Other
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david.c.sterratt@ed.ac.uk
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Groen, Martine R
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