SenseLab
Computational model
  Data
CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
NEURON files from the paper: Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations. PLoS ONE 7(5): e36867. doi:10.1371/journal.pone.0036867. Experimental findings on the effects of Ih current modulation, which is particularly involved in epilepsy, appear to be inconsistent. In the paper, using a realistic model we show how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Migliore, Michele [Michele.Migliore at Yale.edu] Show Other
rosanna.migliore@pa.ibf.cnr.it
True
False
Other categories referring to CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
Revisions: 22
Last Time: 1/2/2015 10:35:31 PM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin