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Paradoxical GABA-mediated excitation (Lewin et al. 2012)
"GABA is the key inhibitory neurotransmitter in the adult central nervous system, but in some circumstances can lead to a paradoxical excitation that has been causally implicated in diverse pathologies from endocrine stress responses to diseases of excitability including neuropathic pain and temporal lobe epilepsy. We undertook a computational modeling approach to determine plausible ionic mechanisms of GABAA-dependent excitation in isolated post-synaptic CA1 hippocampal neurons because it may constitute a trigger for pathological synchronous epileptiform discharge. In particular, the interplay intracellular chloride accumulation via the GABAA receptor and extracellular potassium accumulation via the K/Cl co-transporter KCC2 in promoting GABAA-mediated excitation is complex. ..."
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Lewin N, Aksay E, Clancy CE (2012) Show Other
  • Clancy, Colleen E [ceclancy at ucdavis.edu] Show Other
tom.morse@yale.edu
KCC2, NKCC1, CALCIUM PUMP,
False
False
Other categories referring to Paradoxical GABA-mediated excitation (Lewin et al. 2012)
Revisions: 3
Last Time: 2/26/2018 11:41:36 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin