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Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
The role of amyloid beta (Aß) in brain function and in the pathogenesis of Alzheimer’s disease remains elusive. Recent publications reported that an increase in Aß concentration perturbs presynaptic release in hippocampal neurons, in particular by increasing release probability of CA3-CA1 synapses. The model predics how this alteration can affect synaptic plasticity and signal integration. The results suggest that the perturbation of release probability induced by increased Aß can significantly alter the spike probability of CA1 pyramidal neurons and thus contribute to abnormal hippocampal function during Alzheimer’s disease.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H (2013) Show Other
  • Bianchi, Daniela [danielabianchi12 -at- gmail.com] Show Other
  • Romani, Armando [romani.armando -at- gmail.com] Show Other
romani.armando@gmail.com
romani.armando@gmail.com
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Revisions: 17
Last Time: 2/12/2013 10:01:29 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin