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Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)
These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
  • Hippocampus CA3 pyramidal GLU cell Show Other
  • Narayanan, Rishikesh [rishi at iisc.ac.in] Show Other
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Revisions: 10
Last Time: 1/2/2015 10:07:21 PM
Reviewer: Robert A McDougal
Owner: Rishikesh Narayanan