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Data
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Effects of Chloride accumulation and diffusion on GABAergic transmission (Jedlicka et al 2011)
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"In the CNS, prolonged activation of GABA(A) receptors (GABA(A)Rs) has been shown to evoke biphasic postsynaptic responses, consisting of an initial hyperpolarization followed by a depolarization.
A potential mechanism underlying the depolarization is an acute chloride (Cl(-)) accumulation resulting in a shift of the GABA(A) reversal potential (E(GABA)).
The amount of GABA-evoked Cl(-) accumulation and accompanying depolarization depends on presynaptic and postsynaptic properties of GABAergic transmission, as well as on cellular morphology and regulation of Cl(-) intracellular concentration ([Cl(-)](i)).
To analyze the influence of these factors on the Cl(-) and voltage behavior, we studied spatiotemporal dynamics of activity-dependent [Cl(-)](i) changes in multicompartmental models of hippocampal cells based on realistic morphological data.
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Jedlicka P, Deller T, Gutkin BS, Backus KH (2011) Show
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Jedlicka, Peter [jedlicka at em.uni-frankfurt.de] Show
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Mohapatra, Namrata [mohapatra at em.uni-frankfurt.de] Show
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namrata.mohapatra@Stud.uni-frankfurt.de
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I Bicarbonate
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Jedlicka, Peter <jedlicka@em.uni-frankfurt.de> Mohapatra, Namrata <namrata.mohapatra@Stud.uni-frankfurt.de>
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