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Effects of Chloride accumulation and diffusion on GABAergic transmission (Jedlicka et al 2011)
"In the CNS, prolonged activation of GABA(A) receptors (GABA(A)Rs) has been shown to evoke biphasic postsynaptic responses, consisting of an initial hyperpolarization followed by a depolarization. A potential mechanism underlying the depolarization is an acute chloride (Cl(-)) accumulation resulting in a shift of the GABA(A) reversal potential (E(GABA)). The amount of GABA-evoked Cl(-) accumulation and accompanying depolarization depends on presynaptic and postsynaptic properties of GABAergic transmission, as well as on cellular morphology and regulation of Cl(-) intracellular concentration ([Cl(-)](i)). To analyze the influence of these factors on the Cl(-) and voltage behavior, we studied spatiotemporal dynamics of activity-dependent [Cl(-)](i) changes in multicompartmental models of hippocampal cells based on realistic morphological data. ..."
  • Jedlicka P, Deller T, Gutkin BS, Backus KH (2011) Show Other
  • Jedlicka, Peter [jedlicka at em.uni-frankfurt.de] Show Other
  • Mohapatra, Namrata [mohapatra at em.uni-frankfurt.de] Show Other
namrata.mohapatra@Stud.uni-frankfurt.de
I Bicarbonate
Jedlicka, Peter <jedlicka@em.uni-frankfurt.de> Mohapatra, Namrata <namrata.mohapatra@Stud.uni-frankfurt.de>
20575006
True
False
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Revisions: 8
Last Time: 7/26/2015 1:07:43 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin