BrainPharm: Computational model - Using Strahler's analysis to reduce realistic models (Marasco et al, 2013)

Computational model

Data

Name

Using Strahler's analysis to reduce realistic models (Marasco et al, 2013)

Submitter name

Pipeline ID

Model File

PurkReductionOnLine [420433]

Notes

Building on our previous work (Marasco et al., (2012)), we present a general reduction method based on Strahler's analysis of neuron morphologies. We show that, without any fitting or tuning procedures, it is possible to map any morphologically and biophysically accurate neuron model into an equivalent reduced version. Using this method for Purkinje cells, we demonstrate how run times can be reduced up to 200-fold, while accurately taking into account the effects of arbitrarily located and activated synaptic inputs.

Model Neurons

Hippocampus CA1 pyramidal GLU cell Show Other
Cerebellum Purkinje GABA cell Show Other

More Cells

Model Currents

I Na,t Show Other
I T low threshold Show Other
I K Show Other
I Calcium Show Other
Ca pump Show Other

Model Receptors

AMPA Show Other

Model Type

Neuron or other electrically excitable cell Show Other
Dendrite Show Other

Model Concept

Activity Patterns Show Other
Active Dendrites Show Other
Influence of Dendritic Geometry Show Other
Detailed Neuronal Models Show Other
Action Potentials Show Other
Synaptic Integration Show Other

Simulator software

NEURON Show Other

Model papers

Marasco A, Limongiello A, Migliore M (2013) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

149000

Region Organism

Hippocampus Show Other
Cerebellum Show Other

Model ID Number

Gap Junctions

Implemented by

Limongiello, Alessandro [alessandro.limongiello at unina.it] Show Other

Public Submitter Email Address

Other Neuron

Model Neurotransmitters

Glutamate Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Using Strahler's analysis to reduce realistic models (Marasco et al, 2013)

Revisions:	18
Last Time:	5/16/2022 4:05:22 PM
Reviewer:	System Administrator
Owner:	Michele Migliore