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A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
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This is a two-layer biophysical olfactory bulb (OB) network model to study cholinergic neuromodulation. Simulations show that nicotinic receptor activation sharpens mitral cell receptive field, while muscarinic receptor activation enhances network synchrony and gamma oscillations. This general model suggests that the roles of nicotinic and muscarinic receptors in OB are both distinct and complementary to one another, together regulating the effects of ascending cholinergic inputs on olfactory bulb transformations.
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Olfactory bulb main mitral GLU cell Show
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Olfactory bulb main interneuron periglomerular GABA cell Show
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Olfactory bulb main interneuron granule MC GABA cell Show
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149739
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Li, Guoshi [guoshi_li at med.unc.edu] Show
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gl275@cornell.edu
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