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Biologically Constrained Basal Ganglia model (BCBG model) (Lienard, Girard 2014)
code_bcbg [42312]
We studied the physiology and function of the basal ganglia through the design of mean-field models of the whole basal ganglia. The parameterizations are optimized with multi-objective evolutionary algorithm to respect best a collection of numerous anatomical data and electrophysiological data. The main outcomes of our study are: • The strength of the GPe to GPi/SNr connection does not support opposed activities in the GPe and GPi/SNr. • STN and MSN target more the GPe than the GPi/SNr. • Selection arises from the structure of the basal ganglia, without properly segregated direct and indirect pathways and without specific inputs from pyramidal tract neurons of the cortex. Selection is enhanced when the projection from GPe to GPi/SNr has a diffuse pattern.
  • Neostriatum medium spiny direct pathway GABA cell Show Other
  • Neostriatum medium spiny indirect pathway GABA cell Show Other
  • Neocortex U1 L5B pyramidal pyramidal tract GLU cell Show Other
  • Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Substantia nigra pars reticulata principal GABA cell Show Other
  • Girard, Benoit [girard at isir.upmc.fr] Show Other
  • Liénard, Jean [lienard at isir.upmc.fr] Show Other
lienard@isir.upmc.fr
Liénard, Jean <lienard@isir.upmc.fr>
False
False
Other categories referring to Biologically Constrained Basal Ganglia model (BCBG model) (Lienard, Girard 2014)
Revisions: 10
Last Time: 12/2/2015 11:04:24 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin