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Data
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Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
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"… We present a new event-driven algorithm to synchronize different neuronal
models, which decreases computational time and avoids superfluous synchronizations.
The algorithm is implemented in the TimeScales framework.
We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum.
The model comprises over a thousand dendritic spines, where the electrical model interacts with the
respective instances of a biochemical model.
Our results show that a multiscale model is able to exhibit changes of synaptic
plasticity as a result of the interaction between electrical and biochemical signaling.
…"
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Neostriatum medium spiny direct pathway GABA cell Show
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Mattioni, Michele [mattioni at ebi.ac.uk] Show
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tom.morse@yale.edu
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