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Data
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Striatal Output Neuron (Mahon, Deniau, Charpier, Delord 2000)
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Striatal output neurons (SONs) integrate glutamatergic synaptic inputs originating from the cerebral cortex. In vivo electrophysiological data have shown that a prior depolarization of SONs induced a short-term (1 sec)increase in their membrane excitability, which facilitated the ability of corticostriatal synaptic potentials to induce firing. Here we propose, using a computational model of SONs, that the use-dependent, short-term increase in the responsiveness of SONs mainly results from the slow kinetics of a voltage-dependent, slowly inactivating potassium A-current. This mechanism confers on SONs a form of intrinsic short-term memory that optimizes the synaptic input–output relationship as a function of their past activation.
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Neostriatum medium spiny direct pathway GABA cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Mahon S, Deniau JM, Charpier S, Delord B (2000) Show
Other
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Biddell, Kevin [kevin.biddell at gmail.com] Show
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kevin.biddell@gmail.com
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