Computational model
Striatal Output Neuron (Mahon, Deniau, Charpier, Delord 2000)
Striatal output neurons (SONs) integrate glutamatergic synaptic inputs originating from the cerebral cortex. In vivo electrophysiological data have shown that a prior depolarization of SONs induced a short-term (1 sec)increase in their membrane excitability, which facilitated the ability of corticostriatal synaptic potentials to induce firing. Here we propose, using a computational model of SONs, that the use-dependent, short-term increase in the responsiveness of SONs mainly results from the slow kinetics of a voltage-dependent, slowly inactivating potassium A-current. This mechanism confers on SONs a form of intrinsic short-term memory that optimizes the synaptic input–output relationship as a function of their past activation.
  • Neostriatum medium spiny direct pathway GABA cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Mahon S, Deniau JM, Charpier S, Delord B (2000) Show Other
  • Biddell, Kevin [kevin.biddell at] Show Other
PMID: 11040268
Other categories referring to Striatal Output Neuron (Mahon, Deniau, Charpier, Delord 2000)
Revisions: 5
Last Time: 1/2/2015 10:34:35 PM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin