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Data
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Calcium influx during striatal upstates (Evans et al. 2013)
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"...
To
investigate the mechanisms that underlie the relationship between
calcium and AP timing, we have developed a realistic biophysical
model of a medium spiny neuron (MSN).
...
Using this model, we found that either the slow inactivation of
dendritic sodium channels (NaSI) or the calcium inactivation of
voltage-gated calcium channels (CDI) can cause high calcium corresponding
to early APs and lower calcium corresponding to later APs.
We found that only CDI can account for the experimental observation
that sensitivity to AP timing is dependent on NMDA receptors.
Additional simulations demonstrated a mechanism by which MSNs
can dynamically modulate their sensitivity to AP timing and show that
sensitivity to specifically timed pre- and postsynaptic pairings (as in
spike timing-dependent plasticity protocols) is altered by the timing of
the pairing within the upstate.
…"
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Neostriatum medium spiny direct pathway GABA cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Evans RC, Maniar YM, Blackwell KT (2013) Show
Other
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Evans, Rebekah [Rebekah.Evans at nih.gov] Show
Other
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tom.morse@yale.edu
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