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Data
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Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
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" ... We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class
(pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of Ih.
Our model
demonstrated that modulation of pyramidal and basket Ih allows tuning theta and gamma oscillation frequency and
amplitude. Pyramidal Ih also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards
particular phases of the theta cycle, effected via Ih’s ability to set pyramidal excitability. ..."
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Hippocampus CA3 pyramidal GLU cell Show
Other
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Hippocampus CA3 interneuron basket GABA cell Show
Other
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Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron Show
Other
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Neymotin SA, Hilscher MM, Moulin TC, Skolnick Y, Lazarewicz MT, Lytton WW (2013) Show
Other
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ca3ihdemo
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Lazarewicz, Maciej [mlazarew at gmu.edu] Show
Other
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Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show
Other
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