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Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
ca3ihdemo_r2 [219536]
" ... We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of Ih. Our model demonstrated that modulation of pyramidal and basket Ih allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal Ih also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards particular phases of the theta cycle, effected via Ih’s ability to set pyramidal excitability. ..."
  • Hippocampus CA3 pyramidal GLU cell Show Other
  • Hippocampus CA3 interneuron basket GABA cell Show Other
  • Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron Show Other
  • Neymotin SA, Hilscher MM, Moulin TC, Skolnick Y, Lazarewicz MT, Lytton WW (2013) Show Other
ca3ihdemo
  • Lazarewicz, Maciej [mlazarew at gmu.edu] Show Other
  • Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show Other
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Revisions: 15
Last Time: 3/18/2017 10:17:28 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Samuel Neymotin