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Data
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Stochastic model of the olfactory cilium transduction and adaptation (Antunes et al 2014)
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" ... In this work, we have combined stochastic computational modeling and
a systematic pharmacological study of different signaling pathways to
investigate their impact during short-term adaptation (STA).
...
These results suggest that G-coupled
receptors (GPCRs) cycling is involved with the occurrence of STA. To
gain insights on the dynamical aspects of this process, we developed
a stochastic computational model. The model consists of the olfactory
transduction currents mediated by the cyclic nucleotide gated (CNG)
channels and calcium ion (Ca2+)-activated chloride (CAC) channels,
and the dynamics of their respective ligands, cAMP and Ca2+, and it
simulates the EOG (electroolfactogram)
results obtained under different experimental
conditions through changes in the amplitude and duration of cAMP and
Ca2+ response, two second messengers implicated with STA
occurrence. The model reproduced the experimental data for each
pharmacological treatment and provided a mechanistic explanation for
the action of GPCR cycling in the levels of second messengers
modulating the levels of STA. All together, these experimental and
theoretical results indicate the existence of a mechanism of
regulation of STA by signaling pathways that control GPCR cycling and
tune the levels of second messengers in OSNs, and not only by CNG
channel desensitization as previously thought. "
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Antunes G, Sebastião AM, Simoes de Souza FM (2014) Show
Other
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AntunesEtAl2014
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Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br] Show
Other
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fabiomarques@fm.ul.pt
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Simoes de Souza, Fabio <fabiomarques@fm.ul.pt>
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