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Optical stimulation of a channelrhodopsin-2 positive pyramidal neuron model (Foutz et al 2012)
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A computational tool to explore the underlying principles of optogenetic neural stimulation. This "light-neuron" model consists of theoretical representations of the light dynamics generated by a fiber optic in brain tissue, coupled to a multicompartment cable model of a cortical pyramidal neuron (Hu et al. 2009, ModelDB #123897) embedded with channelrhodopsin-2 (ChR2) membrane dynamics. Simulations predict that the activation threshold is sensitive to many of the properties of ChR2 (density, conductivity, and kinetics), tissue medium (scattering and absorbance), and the fiber-optic light source (diameter and numerical aperture). This model system represents a scientific instrument to characterize the effects of optogenetic neuromodulation, as well as an engineering design tool to help guide future development of optogenetic technology.
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Foutz TJ, Arlow RL, McIntyre CC (2012) Show
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FoutzEtAl2012
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MacIntyre, CC [ccm4 at case.edu] Show
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Foutz, Thomas J [tfoutz at uw.edu] Show
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Arlow, Richard L [richard.arlow at case.edu] Show
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tom.foutz@gmail.com
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Foutz, Thomas J <tfoutz at uw.edu>; McIntyre, Cameron C <ccm4 at case.edu>; Arlow, Richard L <richard.arlow at case.edu>
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