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Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
RowanEtAl2014_r1 [635458]
"... As cells die and synapses lose their drive, remaining cells suffer an initial decrease in activity. Neuronal homeostatic synaptic scaling then provides a feedback mechanism to restore activity. ... The scaling mechanism increases the firing rates of remaining cells in the network to compensate for decreases in network activity. However, this effect can itself become a pathology, ... Here, we present a mechanistic explanation of how directed brain stimulation might be expected to slow AD progression based on computational simulations in a 470-neuron biomimetic model of a neocortical column. ... "
  • Neocortex V1 L6 pyramidal corticothalamic GLU cell Show Other
  • Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Neocortex V1 interneuron basket PV GABA cell Show Other
  • Neocortex fast spiking (FS) interneuron Show Other
  • Neocortex spiny stellate cell Show Other
  • Neocortex spiking regular (RS) neuron Show Other
  • Neocortex spiking low threshold (LTS) neuron Show Other
  • Rowan MS, Neymotin SA, Lytton WW (2014) Show Other
  • Lytton, William [bill.lytton at downstate.edu] Show Other
  • Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show Other
  • Rowan, Mark [m.s.rowan at cs.bham.ac.uk] Show Other
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Revisions: 10
Last Time: 2/15/2017 1:55:20 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin