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Data
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Dentate gyrus network model (Tejada et al 2014)
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" ... Here we adapted an existing computational model of the dentate gyrus (J Neurophysiol 93: 437-453, 2005) by replacing the reduced granule cell models with morphologically detailed models coming from (3D) reconstructions of mature cells.
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Different fractions of the mature granule cell models were replaced by morphologically reconstructed models of newborn dentate granule cells from animals with PILO-induced Status Epilepticus, which have apical dendritic alterations and spine loss, and control animals, which do not have these alterations.
This complex arrangement of cells and processes allowed us to study the combined effect of mossy fiber sprouting, altered apical dendritic tree and dendritic spine loss in newborn granule cells on the excitability of the dentate gyrus model.
Our simulations suggest that alterations in the apical dendritic tree and dendritic spine loss in newborn granule cells have opposing effects on the excitability of the dentate gyrus after Status Epilepticus. Apical dendritic alterations potentiate the increase of excitability provoked by mossy fiber sprouting while spine loss curtails this increase.
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Tejada J, Garcia-Cairasco N, Roque AC (2014) Show
Other
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Tejada J, Arisi GM, García-Cairasco N, Roque AC (2012) Show
Other
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155568
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Tejada, Julian [julian.tejada at gmail.com] Show
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julian.tejada@gmail.com
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Neurogenesis
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Tejada, Julian <julian.tejada@gmail.com>
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http://www.ncbi.nlm.nih.gov/pubmed/24811867
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