SenseLab
Computational model
  Data
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
Among the rhythmic firing patterns observed in brain, gamma oscillations, which are involved in memory formation and retrieval, are generated by networks of fast-spiking basket cells (FS-BCs) with robust interconnectivity through fast GABA synapses. Recently, we identified presence of extrasynaptic tonic GABA currents in FS-BCs and showed that experimentally-induced seizures enhance extrasynaptic tonic GABA currents and render GABA reversal potential (EGABA) depolarizing (Yu et al., 2013). Extrasynaptic GABA currents are mediated by extra- and peri-synaptically located GABAARs and can contribute to synaptic decay kinetics. Additionally, shunting rather than hyperpolarizing EGABA has been shown to increase the frequency and reduce coherence of network oscillations. Using homogeneous networks of biophysically-based, multi-compartmental model FS-BCs, we examined how the presence of extrasynaptic GABA currents and the experimentally identified seizure-induced alterations in GABA currents and EGABA modify the frequency and coherence of network firing.
  • Neuron or other electrically excitable cell Show Other
  • Proddutur A, Yu J, Elgammal FS, Santhakumar V (2013) Show Other
ap269@njit.edu
ExtrasynapticGABAa
24387588
False
False
Other categories referring to Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
Revisions: 10
Last Time: 2/26/2018 11:46:24 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin