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Data
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Theoretical reconstrucion of field potentials and dendrodendritic synaptic...(Rall & Shepherd 1968)
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This
was the first application of compartmental modeling using the Rall
approach to brain neurons. It combined multicompartmental representation
of a mitral cell and a granule cell with the first Hodgkin-Huxley-like
action potential
to model antidromic activation of the mitral cell, followed by synaptic
excitation of the granule cell and synaptic inhibition of the mitral cell.
Combined with reconstruction of the field
potentials generated around these neurons, and detailed comparisons with
single
cell recordings, it led to prediction of dendrodendritic interactions
mediating
self and lateral inhibition of the mitral cells by the granule cells. It
has been regarded as
the first computational model of a brain microcircuit (see also Shepherd
and Brayton, 1979). Recreation of the model is pending.
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tom.morse@yale.edu
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