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Data
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Model of AngII signaling and membrane electrophysiology (Makadia, Anderson, Fey et al., 2015)
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We developed a novel multiscale model to bridge neuropeptide receptor-activated signaling pathway with membrane electrophysiology.
The model studies the effects of Angiotensin II (AngII) on neuronal excitability changes mediated by signaling dynamics and downstream
phosphorylation of ion channels. The multiscale model was implemented as a set of ordinary differential equations solved using the ode15s
solver in Matlab (Mathworks, USA). The signaling reactions were modeled with either mass-action or Michaelis--Menten kinetics and ion
channel electrophysiology was modeled according to the Hodgkin-Huxley formalism. These models were initially validated against their
respective data domains independently and were integrated to develop a multiscale model of signaling and electrophysiology.
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Neuron or other electrically excitable cell Show
Other
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Makadia HK, Anderson WD, Fey D, Sauter T, Schwaber JS, Vadigepalli R (2015) Show
Other
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Makadia, Hirenkumar K [hiren.makadia at gmail.com] Show
Other
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Anderson, Warren D [warren.anderson at jefferson.edu] Show
Other
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Fey, Dirk [dirk.fey at ucd.ie] Show
Other
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Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu] Show
Other
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hiren.makadia@gmail.com
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