BrainPharm: Computational model - Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014)

Computational model

Data

Name

Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014)

Submitter name

Pipeline ID

Model File

sd [?]

Notes

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na+ channel. This genetic defect affects the inactivation gate. The code describes an extended Hodgkin-Huxley framework with dynamic ion concentrations in a wilde-type and mutant form.

Model Neurons

More Cells

Model Currents

I Na,t Show Other
I K Show Other
I K,leak Show Other
Na/K pump Show Other
I Cl, leak Show Other
I Na, leak Show Other

Model Receptors

Model Type

Neuron or other electrically excitable cell Show Other

Model Concept

Simulator software

XPPAUT Show Other

Model papers

Dahlem MA, Schumacher J, Hübel N (2014) Show Other

Gene

Nav1.1 SCN1A Show Other

hg folder name (applicable when in ModelDB hg)

Region Organism

Model ID Number

Gap Junctions

Implemented by

Public Submitter Email Address

markus.dahlem@gmail.com

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Spreading depression

Other Simulator

Other Implementer

Alternative Version

Citation

24860703

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014)

Revisions:	3
Last Time:	10/8/2014 10:12:54 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin