SenseLab
Computational model
  Data
Rhesus Monkey Layer 3 Pyramidal Neurons: Young vs aged PFC (Coskren et al. 2015)
CoskrenEtAl2015 [30288656]
Layer 3 (L3) pyramidal neurons in the lateral prefrontal cortex (LPFC) of rhesus monkeys exhibit dendritic regression, spine loss and increased action potential (AP) firing rates during normal aging. The relationship between these structural and functional alterations, if any, is unknown. Computational models using the digital reconstructions with Hodgkin-Huxley and AMPA channels allowed us to assess relationships between demonstrated age-related changes and to predict physiological changes that have not yet been tested empirically. Tuning passive parameters for each model predicted significantly higher membrane resistance (Rm) in aged versus young neurons. This Rm increase alone did not account for the empirically observed fI-curves, but coupling these Rm values with subtle differences in morphology and membrane capacitance Cm did. The predicted differences in passive parameters (or other parameters with similar effects) are mathematically plausible, but must be tested empirically.
  • Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM (2015) Show Other
  • Weaver, Christina [christina.weaver at fandm.edu] Show Other
christina.weaver@fandm.edu
Coskren PJ, Luebke JI, Kabaso BD, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM. Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. Submitted to the Journal of Computational Neuroscience (2014).
False
False
Other categories referring to Rhesus Monkey Layer 3 Pyramidal Neurons: Young vs aged PFC (Coskren et al. 2015)
Revisions: 7
Last Time: 8/12/2015 4:28:21 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin