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Neuronal dendrite calcium wave model (Neymotin et al, 2015)
ca1dDemo_r1 [179258]
"... We developed a reaction-diffusion model of an apical dendrite with diffusible inositol triphosphate (IP3 ), diffusible Ca2+, IP3 receptors (IP3 Rs), endoplasmic reticulum (ER) Ca2+ leak, and ER pump (SERCA) on ER. ... At least two modes of Ca2+ wave spread have been suggested: a continuous mode based on presumed relative homogeneity of ER within the cell; and a pseudo-saltatory model where Ca2+ regeneration occurs at discrete points with diffusion between them. We compared the effects of three patterns of hypothesized IP3 R distribution: 1. continuous homogeneous ER, 2. hotspots with increased IP3R density (IP3 R hotspots), 3. areas of increased ER density (ER stacks). All three modes produced Ca2+ waves with velocities similar to those measured in vitro (~50 - 90┬Ám /sec). ... The measures were sensitive to changes in density and spacing of IP3 R hotspots and stacks. ... An extended electrochemical model, including voltage gated calcium channels and AMPA synapses, demonstrated that membrane priming via AMPA stimulation enhances subsequent Ca2+ wave amplitude and duration. Our modeling suggests that pharmacological targeting of IP3 Rs and SERCA could allow modulation of Ca2+ wave propagation in diseases where Ca2+ dysregulation has been implicated. "
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Hippocampus CA3 pyramidal GLU cell Show Other
  • Neocortex V1 L6 pyramidal corticothalamic GLU cell Show Other
  • Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Neymotin SA, McDougal RA, Sherif MA, Fall CP, Hines ML, Lytton WW (2015) Show Other
ca1dDemo
  • Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show Other
  • McDougal, Robert [robert.mcdougal at yale.edu] Show Other
  • Sherif, Mohamed [mohamed.sherif.md at gmail.com] Show Other
mohamed.sherif.md@gmail.com
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Revisions: 11
Last Time: 9/15/2016 1:48:22 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin