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Data
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Neuronal dendrite calcium wave model (Neymotin et al, 2015)
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"...
We developed a reaction-diffusion model of an apical dendrite with diffusible inositol triphosphate (IP3 ), diffusible Ca2+, IP3 receptors (IP3 Rs), endoplasmic reticulum (ER) Ca2+ leak, and ER pump (SERCA) on ER.
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At least two modes of Ca2+ wave spread have been suggested: a continuous mode based on presumed relative homogeneity of ER within the cell; and a pseudo-saltatory model where Ca2+ regeneration occurs at discrete points with diffusion between them.
We compared the effects of three patterns of hypothesized IP3 R distribution: 1. continuous homogeneous ER, 2. hotspots with increased IP3R density (IP3 R hotspots), 3. areas of increased ER density (ER stacks). All three modes produced Ca2+ waves with velocities similar to those measured in vitro (~50 - 90µm /sec). ...
The measures were sensitive to changes in density and spacing of IP3 R hotspots and stacks.
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An extended electrochemical model, including voltage gated calcium channels and AMPA synapses, demonstrated that membrane priming via AMPA stimulation enhances subsequent Ca2+ wave amplitude and duration. Our modeling suggests that pharmacological targeting of IP3 Rs and SERCA could allow modulation of Ca2+ wave propagation in diseases where Ca2+ dysregulation has been implicated.
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Hippocampus CA1 pyramidal GLU cell Show
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Hippocampus CA3 pyramidal GLU cell Show
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Neocortex L5/6 pyramidal GLU cell Show
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Neocortex L2/3 pyramidal GLU cell Show
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Neymotin SA, McDougal RA, Sherif MA, Fall CP, Hines ML, Lytton WW (2015) Show
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ca1dDemo
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Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show
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McDougal, Robert [robert.mcdougal at yale.edu] Show
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Sherif, Mohamed [mohamed.sherif.md at gmail.com] Show
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mohamed.sherif.md@gmail.com
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