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Data
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Active zone model of Ca2+ secretion coupling (Keller et al. 2015)
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"... At a large model synapse, the calyx of Held, transmitter release is controlled by several Ca2+ channels in a "domain overlap" mode, at least in young animals. To study the geometrical constraints of Ca2+ channel placement in domain overlap control of release, we used stochastic MCell modelling, at active zones for which the position of docked vesicles was derived from electron microscopy (EM).
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Keller D, Babai N, Kochubey O, Han Y, Markram H, Schürmann F, Schneggenburger R (2015) Show
Other
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dkeller@eskimo.com
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Calyx of Held
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Vesicle Release
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Keller D, Babai N, Kochubey O, Han Y, Markram H, Schürmann F, et al. (2015) An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse. PLoS Comput Biol 11(5): e1004253. doi:10.1371/journal.pcbi.1004253
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