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Substantia nigra pars reticulata principal GABA cell
GABAergic projection neurons that transmit information from the basal ganglia circuit to the thalamus and superior colliculus.
184
 Neuronal Receptors (37)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Proximal equivalent dendrite NMDA subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
2 Yes Middle equivalent dendrite GabaA striatonigral and pallidonigral input The reversal potential as well asthe complete blockade of the striatal-evokedsynaptic events by bicuculline or picrotoxin indicatethat neurotransmission between striatonigralfibers and SNr cells is due to activation of GABAAreceptors with chloride ions as charge carriers"
3 Yes Distal equivalent dendrite Dopaminergic Receptor spontaneously released dopamine from dopamine dendrites induces tonic activation of D1-like receptors and exerts a tonic excitatory influence on SNr GABA neurons"
4 Yes Middle equivalent dendrite TrpM3 Using ex vivo slices of guinea pig midbrain, we show that SNr GABAergic neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced burst firing. Furthermore, we show that spontaneous firing rate and burst activity are modulated by the reactive oxygen species H(2)O(2) acting via TRPM2 channels. Thus, our results indicate that activation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsiveness to modulatory H(2)O(2).”
5 Yes Middle equivalent dendrite mGluR5 subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
6 Yes Soma Glycine At the subcellular level in the substantia nigra pars reticulata (SNr), GlyRs show a localized distribution on the soma and dendrites that partially complements but does not overlap with the distribution of gamma-aminobutyric acid (GABA)A receptors."
7 Yes Middle equivalent dendrite Glycine At the subcellular level in the substantia nigra pars reticulata (SNr), GlyRs show a localized distribution on the soma and dendrites that partially complements but does not overlap with the distribution of gamma-aminobutyric acid (GABA)A receptors."
8 Yes Middle equivalent dendrite NMDA subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
9 Yes Proximal equivalent dendrite AMPA subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
10 Yes Proximal equivalent dendrite mGluR1 subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
11 Yes Distal equivalent dendrite mGluR5 subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
12 Yes Proximal equivalent dendrite Dopaminergic Receptor spontaneously released dopamine from dopamine dendrites induces tonic activation of D1-like receptors and exerts a tonic excitatory influence on SNr GABA neurons."
13 Yes Proximal equivalent dendrite 5-HT2 Raphe nucleus Histochemical studies have established that SNr receivesdense 5-HT innervation originating from 5-HT neurons inraphe nuclei.”
14 Yes Distal equivalent dendrite Nicotinic acetylcholine receptors.
15 Yes Middle equivalent dendrite Nicotinic acetylcholine receptors.
16 Yes Proximal equivalent dendrite Muscarinic acetylcholine receptors.
17 Yes Distal equivalent dendrite TrpM3 Using ex vivo slices of guinea pig midbrain, we show that SNr GABAergic neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced burst firing. Furthermore, we show that spontaneous firing rate and burst activity are modulated by the reactive oxygen species H2O2 acting via TRPM2 channels. Thus, our results indicate that activation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsiveness to modulatory H2O2.”
18 Yes Proximal equivalent dendrite mGluR5 subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
19 Yes Proximal equivalent dendrite Nicotinic acetylcholine receptors.
20 Yes Middle equivalent dendrite GabaB striatonigral and pallidonigral input The presence of GABAB receptor subtypes BR1 and BR2 on the presynaptic and postsynaptic membranes of GABAergic striatonigral synapses and glutamatergic STN like terminals indicates that besides GABAA, GABAB receptors are also implicated in GABAergic striatonigral transmission."
21 Yes Proximal equivalent dendrite GabaB striatonigral and pallidonigral input The presence of GABAB receptor subtypes BR1 and BR2 on the presynaptic and postsynaptic membranes of GABAergic striatonigral synapses and glutamatergic STN like terminals indicates that besides GABAA, GABAB receptors are also implicated in GABAergic striatonigral transmission."
22 Yes Proximal equivalent dendrite GabaA striatonigral and pallidonigral input The reversal potential as well asthe complete blockade of the striatal-evokedsynaptic events by bicuculline or picrotoxin indicatethat neurotransmission between striatonigralfibers and SNr cells is due to activation of GABAAreceptors with chloride ions as charge carriers"
23 Yes Distal equivalent dendrite GabaA striatonigral and pallidonigral input The reversal potential as well asthe complete blockade of the striatal-evokedsynaptic events by bicuculline or picrotoxin indicatethat neurotransmission between striatonigralfibers and SNr cells is due to activation of GABAAreceptors with chloride ions as charge carriers"
24 Yes Middle equivalent dendrite mGluR1 subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
25 Yes Distal equivalent dendrite GabaB striatonigral and pallidonigral input The presence of GABAB receptor subtypes BR1 and BR2 on the presynaptic and postsynaptic membranes of GABAergic striatonigral synapses and glutamatergic STN like terminals indicates that besides GABAA, GABAB receptors are also implicated in GABAergic striatonigral transmission."
26 Yes Distal equivalent dendrite mGluR1 subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
27 Yes Middle equivalent dendrite Muscarinic acetylcholine receptors.
28 Yes Distal equivalent dendrite Glycine At the subcellular level in the substantia nigra pars reticulata (SNr), GlyRs show a localized distribution on the soma and dendrites that partially complements but does not overlap with the distribution of gamma-aminobutyric acid (GABA)A receptors."
29 Yes Proximal equivalent dendrite Glycine At the subcellular level in the substantia nigra pars reticulata (SNr), GlyRs show a localized distribution on the soma and dendrites that partially complements but does not overlap with the distribution of gamma-aminobutyric acid (GABA)A receptors."
30 Yes Middle equivalent dendrite AMPA subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
31 Yes Middle equivalent dendrite Dopaminergic Receptor spontaneously released dopamine from dopamine dendrites induces tonic activation of D1-like receptors and exerts a tonic excitatory influence on SNr GABA neurons."
32 Yes Middle equivalent dendrite 5-HT2 Raphe nucleus Histochemical studies have established that SNr receivesdense 5-HT innervation originating from 5-HT neurons inraphe nuclei.”
33 Yes Proximal equivalent dendrite TrpM3 Using ex vivo slices of guinea pig midbrain, we show that SNr GABAergic neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced burst firing. Furthermore, we show that spontaneous firing rate and burst activity are modulated by the reactive oxygen species H(2)O(2) acting via TRPM2 channels. Thus, our results indicate that activation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsiveness to modulatory H(2)O(2).”
34 Yes Distal equivalent dendrite 5-HT2 Raphe nucleus Histochemical studies have established that SNr receivesdense 5-HT innervation originating from 5-HT neurons inraphe nuclei.”
35 Yes Distal equivalent dendrite NMDA subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
36 Yes Distal equivalent dendrite AMPA subthalamonigral input The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
37 Yes Distal equivalent dendrite Muscarinic acetylcholine receptors.
 Neuronal Currents (5)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Soma I K,Ca Reviewed in
2 Yes Soma I Na,p Reviewed in
3 Yes Soma I Calcium Reviewed in
4 Yes Soma I Na,t Reviewed in
5 Yes Soma I K Reviewed in
 Neuronal Transmitters (1)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Gaba Thalamic and cortical connections From rodents to primates, the SNr and GPi innervate thalamic and brain stem nuclei connected to motor, prefrontal, parietal and temporal associative cortical areas offering an access for BG to control motor, cognitive, as well as emotional–motivational processes.”
Other categories referring to Substantia nigra pars reticulata principal GABA cell
Computational model.Model Neurons   (3)
Neuronal Structure.Neurons   (1)
Revisions: 5
Last Time: 6/19/2019 12:27:56 PM
Reviewer: System Administrator
Owner: System Administrator