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Diffusive homeostasis in a spiking network model (Sweeney et al. 2015)
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In this paper we propose a new mechanism, diffusive homeostasis, in which neural excitability is modulated by nitric oxide, a gas which can flow freely across cell membranes. Our model simulates the activity-dependent synthesis and diffusion of nitric oxide in a recurrent network model of integrate-and-fire neurons. The concentration of nitric oxide is then used as homeostatic readout which modulates the firing threshold of each neuron.
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Abstract integrate-and-fire leaky neuron Show
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Sweeney Y, Hellgren Kotaleski J, Hennig MH (2015) Show
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Sweeney, Yann [yann.sweeney at ed.ac.uk] Show
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yann.sweeney@ed.ac.uk
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Volume transmission
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Sweeney Y, Hellgren Kotaleski J, Hennig MH (2015) A Diffusive Homeostatic Signal Maintains Neural Heterogeneity and Responsiveness in Cortical Networks. PLoS Comput Biol 11(7): e1004389. doi: 10.1371/journal.pcbi.1004389
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