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Discharge hysteresis in motoneurons (Powers & Heckman 2015)
"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
  • Spinal cord lumbar motor neuron alpha ACh cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Powers, Randy [rkpowers at u.washington.edu] Show Other
tom.morse@yale.edu
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Revisions: 11
Last Time: 11/16/2016 1:13:49 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin