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Data
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CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
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This model simulates the effects of dendritic sodium spikes initiated in distal apical dendrites on the voltage and the calcium dynamics revealed by calcium imaging. It shows that dendritic sodium spike promotes large and transient calcium influxes via NMDA receptor and L-type voltage-gated calcium channels, which contribute to the induction of LTP at distal synapses.
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Hippocampus CA1 pyramidal GLU cell Show
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Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Show
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Cembrowski, Mark S [cembrowskim at janelia.hhmi.org] Show
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Hsu, Ching-Lung [hsuc at janelia.hhmi.org] Show
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hsuc@janelia.hhmi.org
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Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons
Yujin Kim*, Ching-Lung Hsu*, Mark Cembrowski, Brett Mensh, Nelson Spruston
eLife 2015;10.7554/eLife.06414
DOI: http://dx.doi.org/10.7554/eLife.06414
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