Computational model
Memory savings through unified pre- and postsynaptic STDP (Costa et al 2015)
Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. In these simulations we demonstrate that learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.
  • Neocortex L5/6 pyramidal GLU cell Show Other
  • Costa RP, Froemke RC, Sjöström PJ, van Rossum MC (2015) Show Other
  • Costa, Rui Ponte [ruipontecosta at] Show Other
Rui Ponte Costa, Robert C Froemke, Per Jesper Sjöström, Mark C W van Rossum - Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning, eLife 2015;10.7554/eLife.09457
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