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CA1 pyramidal cell receptor dependent cAMP dynamics (Chay et al. 2016)
ChayEtAl2015 [4812327]
We use a combination of live cell imaging and stochastic modeling of signaling pathways to investigate how noradrenergic receptor stimulation interacts with calcium to control cAMP, required for synaptic plasticity and memory in the hippocampus. Our simulation results explain the mechanism whereby prior noradrenergic receptor stimulation does not enhance the subsequent NMDA stimulated cAMP elevation. Specifically, our results demonstrate the the negative feedback loop from cAMP, through PKA, to PDE4 cannot explain the results, and that switching of the noradrenergic receptor from Gs to Gi is required.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Chay A, Zamparo I, Koschinski A, Zaccolo M, Blackwell KT (2016) Show Other
  • Blackwell, Avrama [avrama at gmu.edu] Show Other
kblackw1@gmu.edu
In final revisions for PLoS Comp Biol
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Other categories referring to CA1 pyramidal cell receptor dependent cAMP dynamics (Chay et al. 2016)
Revisions: 6
Last Time: 3/14/2016 2:50:52 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin