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Spine fusion and branching effects synaptic response (Rusakov et al 1996, 1997)
This compartmental model of a hippocampal granule cell has spinous synapses placed on the second-order dendrites. Changes in shape and connectivity of the spines usually does not effect the synaptic response of the cell unless active conductances are incorporated into the spine membrane (e.g. voltage-dependent Ca2+ channels). With active conductances, spines can generate spike-like events. We showed that changes like fusion and branching, or in fact any increase in the equivalent spine neck resistance, could trigger a dramatic increase in the spine's influence on the dendritic shaft potential.
  • Rusakov DA, Richter-Levin G, Stewart MG, Bliss TV (1997) Show Other
  • Rusakov DA, Stewart MG, Korogod SM (1996) Show Other
spinebranches
  • Rusakov, DA [D.Rusakov at ion.ucl.ac.uk] Show Other
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Last Time: 1/2/2015 10:33:47 PM
Reviewer: Robert A McDougal
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