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Modeling dentate granule cells heterosynaptic plasticity using STDP-BCM rule (Jedlicka et al. 2015)
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... Here we study how key components of learning mechanisms in the brain, namely spike timing-dependent plasticity and metaplasticity, interact with spontaneous activity in the input pathways of the neuron. Using biologically realistic simulations we show that ongoing background activity is a key determinant of the degree of long-term potentiation and long-term depression of synaptic transmission between nerve cells in the hippocampus of freely moving animals. This work helps better understand the computational rules which drive synaptic plasticity in vivo.
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Jedlicka P, Benuskova L, Abraham WC (2015) Show
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Jedlicka, Peter [jedlicka at em.uni-frankfurt.de] Show
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jedlicka@em.uni-frankfurt
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Jedlicka P, Benuskova L, Abraham WC (2015) A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent “Heterosynaptic” LTD in the Dentate Gyrus In Vivo. PLoS Computational Biology
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