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Data
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Axonal spheroids and conduction defects in Alzheimer’s disease (Yuan, Zhang, Tong, et al 2022)
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PAAS (plaque-associated axonal spheroid(s)) are dystrophic structures that sprout from axons that pass through amyloid beta plaques. If small enough they do not interfere with action potential (AP) propagation. Medium sized ones delay APs, and large, or many spheroids can block single APs and block or delay trains of APs.
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Hippocampus CA1 pyramidal GLU cell Show
Other
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Neocortex L5/6 pyramidal GLU cell Show
Other
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Neocortex L2/3 pyramidal GLU cell Show
Other
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Yuan P, Zhang M, Tong L, Morse TM, McDougal RA, Ding H, Chan D, Cai Y, Grutzendler J Show
Other
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Morse, Tom [Tom.Morse at Yale.edu] Show
Other
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McDougal, Robert [robert.mcdougal at yale.edu] Show
Other
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tom.morse@yale.edu
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Yuan, Peng (Paul)
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current
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