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H-currents effect on the fluctuation of gamma/beta oscillations (Avella-Gonzalez et al., 2015)
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Oscar Javier Avella Gonzalez
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This model was designed to study the impact of H-currents on
the dynamics of cortical oscillations, and in paticular on
the occurrence of high and low amplitude episodes (HAE, LAE) in network oscillations.
The H-current is a slow, hyperpolarization-activated, depolarizing current
that contributes to neuronal resonance and membrane potential.
We characterized amplitude fluctuations in network oscillations by measuring
the average durations of HAEs and LAEs, and explored
how these were modulated by trains of external spikes, both in
the presence and absence of H-channels.
We looked at HAE duration, the frequency
and power of network oscillations, and the effect
of H-channels on the temporal voltage profile in single cells.
We found that H-currents increased the oscillation frequency and, in combination with external spikes, representing input from areas outside the network, strongly decreased the synchrony of firing. As a consequence, the oscillation power and the duration of episodes during which the network exhibited high-amplitude oscillations were greatly reduced in the presence of H-channels.
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Abstract single compartment conductance based cell Show
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Avella Gonzalez OJ, Mansvelder HD, van Pelt J, van Ooyen A (2015) Show
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Avella G. Oscar Javier [oscarjavella at gmail dot com] Show
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oscarjavella@gmail.com
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prefrontal cortex
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H-currents, Na current, K current, leak current
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glutamate
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